Publikationen aus dem Verbundprojekt

 

 

Bach K, Huppe D, Schmiegel W, Epplen JT, Kunstmann E. [Evaluation of outpatient management in HNPCC]. Z Gastroenterol 2005 Jul;43 (7):647-51.

 

Baehring J, Sutter C, Kadmon M, von Knebel Doeberitz M, Gebert J. Aberrant Splicing of hMLH1 in a Hereditary Nonpolyposis Colorectal Cancer Kindred – A Novel Mutational Mechanism. Fam Cancer. 2006;5(2):195-9.

 

Berth H, Dinkel A, Balck F. Das Vertrauen der deutschen Bevölkerung in die Durchführung und Ergebnisverwendung genetischer Untersuchungen. J Public Health 2004; 12; 105-110.

 

Bettstetter M, Dechant S, Ruemmele P, Grabowski M, Keller G, Holinski-Feder E, Hartmann A, Hofstaedter F and Dietmaier W. Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin Cancer Res 2007;13(11): 3221-8.

 

Bettstetter M, Woenckhaus M, Wild PJ, Rummele P, Blaszyk H, Hartmann A, Hofstadter F, Dietmaier W. Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer. J Pathol. 2005 Apr;205(5):606-14.

 

Buckowitz A, Knaebel HP, Benner A, Blaker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer. 2005 May 9;92(9):1746-53.

 

Cederquist K, Emanuelsson M, Goransson I, Holinski-Feder E, Muller-Koch Y, Golovleva I, Gronberg H. Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden. Int J Cancer 2004 Apr 10;109 (3):370-6.

 

Davalos V, Dopeso H, Velho S, Ferreira AM, Cirnes L, Diaz-Chico N, Bilbao C,Ramirez R, Rodriguez G, Falcon O, Leon L, Niessen RC, Keller G, Dallenbach-Hellweg G, Espin E, Armengol M, Plaja A, Perucho M, Imai K, Yamamoto H, Gebert JF, Diaz-Chico JC, Hofstra RM, Woerner SM, Seruca R, Schwartz S, Arango D. High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability. Oncogene 2007, 26:308-311.

 

Dellas A, Puhl A, Schraml P, Thomke SE, Ruschoff J, Mihatsch MJ, Moch H. Molecular and clinicopathological analysis of ovarian carcinomas with and without microsatellite instability. Anticancer Res 2004 Jan-Feb;24 (1):361-9.

 

Dietmaier W, Bettstetter M, Wild PJ, Woenckhaus M, Rummele P, Hartmann A, Dechant S, Blaszyk H, Pauer A, Klinkhammer-Schalke M, Hofstadter F. Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer. Int J Cancer. 2005 Dec 5; [Epub ahead of print].

 

Drobinskaya I, Gabbert HE, Moeslein G, Mueller W. A new method for optimizing multiplex DNA microsatellite analysis in low quality archival specimens. Anticancer Res 2005 Sep-Oct;25 (5):3251-8.

 

Duffy MJ, van Dalen A, Haglund C, Hansson L, Holinski-Feder E, Klapdor R, Lamerz R, Peltomaki P, Sturgeon C and Topolcan O. Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur J Cancer 2007; 43(9):1348-1360.

 

Eckert A, Kloor M, Giersch A, Ahmadi R, Herold-Mende C, Hampl JA, Heppner FL, Zoubaa S, Holinski-Feder E, Pietsch T, Wiestler OD, von Knebel Doeberitz M, Roth W and Gebert J. Microsatellite instability in pediatric and adult high-grade gliomas. Brain Pathol 2007;17(2): 146-50.

 

Engel C, Forberg J, Holinski-Feder E, Pagenstecher C, Plaschke J, Kloor M, Poremba C, Pox CP, Ruschoff J, Keller G, Dietmaier W, Rummele P, Friedrichs N, Mangold E, Buettner R, Schackert HK, Kienle P, Stemmler S, Moeslein G, Loeffler M. Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. Int J Cancer 2006 Jan 1;118 (1):115-22.

 

Findeisen P, Kloor M, Merx S, Sutter C, Woerner SM, Dostmann N, Benner A, Dondog B, Pawlita M, Dippold W, Wagner R, Gebert J, von Knebel Doeberitz M. T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer. Cancer Res 2005 Sep 15;65 (18):8072-8.

Friedrichs N; Rahner N; Friedl W; Steinke V, Merkelbach-Bruse S, Propping P, Büttner R, Walldorf C. Erblicher Darmkrebs (HNPCC): eine wichtige Diagnose auch im höheren Lebensalter. Gastroenterologie up2date 2006; Issue 4, Volume 2: 262-266.

 

German HNPCC Consortium, Muller A, Beckmann C, Westphal G, Bocker Edmonston T, Friedrichs N, Dietmaier W, Brasch FE, Kloor M, Poremba C, Keller G, Aust DE, Fass J, Buttner R, Becker H, Ruschoff J. Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study. Int J Colorectal Dis. 2006 Oct;21(7):632-41.

 

Giuffre G, Muller A, Brodegger T, Bocker-Edmonston T, Gebert J, Kloor M, Dietmaier W, Kullmann F, Buttner R, Tuccari G, Ruschoff J. Microsatellite analysis of hereditary nonpolyposis colorectal cancer-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein expression provides new insights in early steps of tumorigenesis. J Mol Diagn 2005 May;7 (2):160-70.

 

Goecke,T., Schulmann,K., Engel,C., Holinski-Feder,E., Pagenstecher,C., Schackert,H.K., Kloor,M., Kunstmann,E., Vogelsang,H., Keller,G., Dietmaier,W., Mangold,E., Friedrichs,N., Propping,P., Kruger,S., Gebert,J., Schmiegel,W., Rueschoff,J., Loeffler,M., and Moeslein,G. Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium. J. Clin. Oncol. 2006; 24, 4285-4292.

 

Gorgens H, Kruger S, Kuhlisch E, Pagenstecher C, Hohl R, Schackert HK, and Muller A. Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH. J. Mol. Diagn. 2006; 8, 178-182.

 

Gottschling S, Reinhard H, Pagenstecher C, Krüger S, Raedle J, Plotz G, Henn W, Buettner R, Meyer S,  Graf N. Possible role of retinoic acid therapy in patients with mismatch repair gene defects. Eur J Pediatr. 2007 Mar 27; [Epub ahead of print]

 

Grabowski M, Mueller-Koch Y, Grasbon-Frodl E, Koehler U, Keller G, Vogelsang H, Dietmaier W, Kopp R, Siebers U, Schmitt W, Neitzel B, Gruber M, Doerner C, Kerker B, Ruemmele P, Henke G, Holinski-Feder E. Deletions account for 17% of pathogenic germline alterations in MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families. Genet Test 2005 Summer;9 (2):138-46.

 

Jones B, Oh C, Mangold E, Egan CA. Muir-Torre syndrome: Diagnostic and screening guidelines. Australas J Dermatol. 2006 Nov;47(4):266-9.

 

Jungck M, Grunhage F, Spengler U, Dernac A, Mathiak M, Caspari R, Friedl W, Sauerbruch T. E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression. Int J Colorectal Dis 2004 Sep;19 (5):438-45.

 

Keller M, Jost R, Kadmon M, Wullenweber HP, Haunstetter CM, Willeke F, Jung C, Gebert J, Sutter C, Herfarth C, Buchler MW. Acceptance of and attitude toward genetic testing for hereditary nonpolyposis colorectal cancer: a comparison of participants and nonparticipants in genetic counseling. Dis Colon Rectum 2004 Feb;47 (2):153-62.

 

Keller G, Vogelsang H, Becker I, Plaschke S, Ott K, Suriano G, Mateus AR, Seruca R, Biedermann K, Huntsman D, Doring C, Holinski-Feder E, Neutzling A, Siewert JR and Hofler H. Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. J Med Genet 2004;41(6): e89.

 

Kloor M, Becker C, Benner A, Woerner SM, Gebert J, Ferrone S, von Knebel Doeberitz M. Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers. Cancer Res 2005 Jul 15;65 (14):6418-24.

 

Kloor M, Michel S, Buckowitz B, Ruschoff J, Buttner R, Holinski-Feder E, Dippold W, Wagner R, Tariverdian M, Benner A, Schwitalle Y, Kuchenbuch B and von Knebel Doeberitz M. Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. Int J Cancer 2007;121(2): 454-458

 

Kloor M, Sutter C, Wentzensen N, Cremer FW, Buckowitz A, Keller M, von Knebel Doeberitz M, Gebert J. A large MSH2 Alu insertion mutation causes HNPCC in a German kindred. Hum Genet 2004 Oct;115 (5):432-8.

 

Koehler A, Bataille F, Schmid C, Ruemmele P, Waldeck A, Blaszyk H, Hartmann A, Hofstaedter F, Dietmaier W. Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage. J Pathol 2004 Sep;204 (1):65-74.

 

Koehler U, Grabowski M, Bacher U and Holinski-Feder E. A new interphase fluorescence in situ hybridization approach for genomic rearrangements involving MLH1 and MSH6 in hereditary nonpolyposis colorectal cancer-suspected mutation-negative patients. Cancer Genet Cytogenet 2007;175(1): 81-4.

 

Kruger S, Bier A, Engel C, Mangold E, Pagenstecher C, von Knebel Doeberitz M, Holinski-Feder E, Moeslein G, Schulmann K, Plaschke J, Rüschoff J, Schackert HK. The p53 codon 72 variation is associated with the age of onset of hereditary non-polyposis colorectal cancer (HNPCC). J Med Genet 2005 Oct;42 (10):769-73.

 

Kruger S, Bier A, Plaschke J, Hohl R, Aust DE, Kreuz FR, Pistorius SR, Saeger HD, Rothhammer V, Al-Taie O, Schackert HK. Ten novel MSH2 and MLH1 germline mutations in families with HNPCC. Hum Mutat 2004 Oct;24 (4):351-2.

 

Kruger S, Engel C, Bier A, Mangold E, Pagenstecher C, von Knebel Doeberitz M, Holinski-Feder E, Moeslein G, Keller G, Kunstmann E, Friedl W, Plaschke J, Rüschoff J, Schackert HK, and The German HNPCC Consortium. Absence of Association between Cyclin D1 (CCND1) G870A Polymorphism and Age of Onset in Hereditary Nonpolyposis Colorectal Cancer. Cancer Lett. 236, 191-197.

 

Kruger,S., Engel,C., Bier,A., Silber,A.S., Gorgens,H., Mangold,E., Pagenstecher,C., Holinski-Feder,E., von Knebel,D.M., Royer-Pokora,B., Dechant,S., Pox,C., Rahner,N., Muller,A., and Schackert,H.K. (2007). The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. Cancer Lett. 252, 55-64

 

Kruger S, Silber AS, Engel C, Gorgens H, Mangold E, Pagenstecher C, Holinski-Feder E, von Knebel Doeberitz M, Moeslein G, Dietmaier W, Stemmler S, Friedl W, Rüschoff J, Schackert HK. Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. Lancet Oncol 2005 Aug;6 (8):566-72.

 

Kunstmann E, Rusche H. [Hereditary intestinal cancer. Linking a specialized center with general medical practice]. Dtsch Med Wochenschr 2004 Jan 2;129 (1-2):23-4.

 

Kunstmann E, Vieland J, Brasch FE, Hahn SA, Epplen JT, Schulmann K, Schmiegel W. HNPCC: six new pathogenic mutations. BMC Med Genet 2004 Jun 24;5:16.

 

Lamberti C, Di Blasi K, Archut D, Fimmers R, Mathiak M, Bollmann M, Vogel J, Kindermann D, Mezger J, Schmidt-Wolf IG, Sauerbruch T. Population-based registration of unselected colorectal cancer patients: five-year survival in the region of Bonn/Rhine-Sieg, Germany. Z Gastroenterol 2005 Feb;43 (2):149-54.

 

Lamberti C, Mangold E, Pagenstecher C, Jungck M, Schwering D, Bollmann M, Vogel J, Kindermann D, Nikorowitsch R, Friedrichs N, Schneider B, Houshdaran F, Schmidt-Wolf IG, Friedl W, Propping P, Sauerbruch T, Büttner R, Mathiak M. Frequency of hereditary non-polyposis colorectal cancer among unselected patients with colorectal cancer in Germany. Digestion. 2006;74(1):58-67.

 

Mangold E, Pagenstecher C, Friedl W, Fischer HP, Merkelbach-Bruse S, Ohlendorf M, Friedrichs N, Aretz S, Buettner R, Propping P, Mathiak M. Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining. J Pathol 2005 Dec;207 (4):385-95.

 

Mangold E, Pagenstecher C, Friedl W, Mathiak M, Buettner R, Engel C, Loeffler M, Holinski-Feder E, Muller-Koch Y, Keller G, Schackert HK, Kruger S, Goecke T, Moeslein G, Kloor M, Gebert J, Kunstmann E, Schulmann K, Ruschoff J, Propping P. Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. Int J Cancer 2005 Sep 20;116 (5):692-702.

 

Mangold E, Pagenstecher C, Leister M, Mathiak M, Rütten A, Friedl W, Propping P, Ruzicka T, Kruse R. A Genotype-Phenotype Correlation in HNPCC: Strong Predominance of MSH2 Mutations in 41 Patients with Muir-Torre Syndrome. J Med Genet 2004; 41:567-572

 

Mangold E, Rahner N, Friedrichs N, Buettner R, Pagenstecher C, Aretz S, Friedl W, Ruzicka T, Propping P, Rutten A, Kruse R. MSH6 mutation in Muir-Torre syndrome: could this be a rare finding? Br J Dermatol. 2007 Jan;156(1):158-62.

 

Martinez R, Schackert HK, Appelt H, Plaschke J, Baretton G, and Schackert G. Low-level microsatellite instability phenotype in sporadic glioblastoma multiforme. J. Cancer Res. Clin. Oncol. 2005; 131, 87-93.

 

Model F, Osborn N, Ahlquist D, Molnar B, Sipos F, Galamb O, Gruetzman R, Pilarsky C, Saeger HD, Rueschoff R, Buettner R, Seitz G, Nimmrich N, Thomas J, Burger M, Maier S, Becker E, Adorja P, Lesche R, Dessauer A, Kleiber J, Portsmann B, Sledziewski A, Lofton-Day C. Identification and validation of colorectal neoplasia-specific methylation marker sequences using genome-wide discovery and microarray analysis. Mol Cancer Res. 2007 Feb;5(2):153-63.

 

Mueller-Koch Y, Vogelsang H, Kopp R, Lohse P, Keller G, Aust D, Muders M, Gross M, Daum J, Schiemann U, Grabowski M, Scholz M, Kerker B, Becker I, Henke G, Holinski-Feder E. HNPCC - clinical and molecular evidence for a new entity of hereditary colorectal cancer. Gut 2005; 54(12):1733-40.

 

Muller A, Beckmann C, Westphal G, Bocker Edmonston T, Friedrichs N, Dietmaier W, Brasch FE, Kloor M, Poremba C, Keller G, Aust DE, Fass J, Buttner R, Becker H, Ruschoff J. Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study. Int J Colorectal Dis 2006 Mar 2.

 

Muller A, Edmonston TB, Dietmaier W, Buttner R, Fishel R, Ruschoff J. MSI-testing in hereditary non-polyposis colorectal carcinoma (HNPCC). Dis Markers 2004;20 (4-5):225-36.

 

Muller A, Giuffre G, Edmonston TB, Mathiak M, Roggendorf B, Heinmoller E, Brodegger T, Tuccari G, Mangold E, Buettner R, Ruschoff J. Challenges and pitfalls in HNPCC screening by microsatellite analysis and immunohistochemistry. J Mol Diagn 2004 Nov;6 (4):308-15.

 

Muller A, Schackert HK, Lange B, Ruschoff J, Fuzesi L, Willert J, Burfeind P, Shah P, Becker H, Epplen JT, Stemmler S. A novel MSH2 germline mutation in homozygous state in two brothers with colorectal cancers diagnosed at the age of 11 and 12 years. Am J Med Genet A 2006 Feb 1;140 (3):195-9.

 

Oberschmid BI, Dietmaier W, Hartmann A, Dahl E, Klopocki E, Beatty BG, Hyman NH, Blaszyk H. Distinct secreted Frizzled receptor protein 1 staining pattern in patients with hyperplastic polyposis coli syndrome. Arch Pathol Lab Med. 2004 Sep;128(9):967-73.

 

Ollila S, Fitzpatrick R, Sarantaus L, Kariola R, Ambus I, Velsher L, Hsieh E, Andersen MK, Raevaara TE, Gerdes AM, Mangold E, Peltomaki P, Lynch HT, Nystrom M. The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC. Int J Oncol. 2006 Jan;28(1):149-153.

 

Ollila S, Sarantaus L, Kariola R, Chan P, Hampel H, Holinski-Feder E, Macrae F, Kohonen-Corish M, Gerdes AM, Peltomaki P, Mangold E, de la Chapelle A, Greenblatt M and Nystrom M. Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein. Gastroenterology 2006;131(5): 1408-17.

 

Pagenstecher C, Wehner M, Friedl W, Rahner N, Aretz S, Friedrichs N, Sengteller M, Henn W, Buettner R, Propping P, Mangold E. Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants. Hum Genet 2006 Mar;119 (1-2):9-22.

 

Pistorius S, Goergens H, Engel C, Plaschke J, Krueger S, Hoehl R, Saeger HD, and Schackert HK. N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. Int. J. Colorectal Dis 2007. 22, 137-143.

 

Pistorius S, Gorgens H, Kruger S, Engel C, Mangold E, Pagenstecher C, Holinski-Feder E, Moeslein G, von Knebel Doeberitz M, Ruschoff J, Karner-Hanusch J, Saeger HD, Schackert HK, The German H-C. N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Lett 2005 Dec 5.

 

Pistorius S, Gorgens H, Plaschke J, Hoehl R, Kruger S, Engel C, Saeger HD, and Schackert HK. Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in HNPCC patients carrying point mutations. Cancer Lett. 2007; 248, 89-95.

 

Pistorius S, Kruger S, Hohl R, Plaschke J, Distler W, Saeger HD, Schackert HK. Occult endometrial cancer and decision making for prophylactic hysterectomy in hereditary nonpolyposis colorectal cancer patients. Gynecol Oncol 2006 Feb 11.

 

Plaschke J, Engel C, Kruger S, Holinski-Feder E, Pagenstecher C, Mangold E, Moeslein G, Schulmann K, Gebert J, von Knebel Doeberitz M, Ruschoff J, Loeffler M, Schackert HK. Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium. J Clin Oncol 2004 Nov 15;22 (22):4486-94.

 

Plaschke J, Kruger S, Dietmaier W, Gebert J, Sutter C, Mangold E, Pagenstecher C, Holinski-Feder E, Schulmann K, Moslein G, Ruschoff J, Engel C, Evans G, Schackert HK. Eight novel MSH6 germline mutations in patients with familial and nonfamilial colorectal cancer selected by loss of protein expression in tumor tissue. Hum Mutat 2004 Mar;23 (3):285.

 

Plaschke J, Kruger S, Jeske B, Theissig F, Kreuz FR, Pistorius S, Saeger HD, Iaccarino I, Marra G, Schackert HK. Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. Cancer Res 2004 Feb 1;64 (3):864-70.

 

Plaschke J, Linnebacher M, Kloor M, Gebert J, Cremer FW, Tinschert S, Aust DE, von Knebel Doeberitz M, Schackert HK. Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor. Eur J Hum Genet 2006 Jan 18.

 

Raevaara TE, Korhonen MK, Lohi H, Hampel H, Lynch E, Lonnqvist KE, Holinski-Feder E, Sutter C, McKinnon W, Duraisamy S, Gerdes AM, Peltomaki P, Kohonen-Ccorish M, Mangold E, Macrae F, Greenblatt M, de la Chapelle A, Nystrom M. Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1. Gastroenterology 2005 Aug; 129(2):537-549.

 

Rahner N, Friedrichs N, Wehner M, Steinke V, Aretz S, Friedl W, Buettner R, Mangold E, Propping P, Walldorf C. Nine Novel Pathogenic Germline Mutations in MLH1, MSH2, MSH6 and PMS2 in Families with Lynch Syndrome. Acta Oncologica 2006, in press.

 

Reinacher-Schick A, Baldus SE, Romdhana B, Landsberg S, Zapatka M, Monig SP, Holscher AH, Dienes HP, Schmiegel W, Schwarte-Waldhoff I. Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas. J Pathol 2004 Apr;202 (4):412-20.

 

Ruschoff J, Roggendorf B, Brasch F, Mathiak M, Aust DE, Plaschke J, Mueller W, Poremba C, Kloor M, Keller G, Muders M, Blasenbreu-Vogt S, Rummele P, Muller A, Buttner R. [Molecular pathology in hereditary colorectal cancer. Recommendations of the Collaborative German Study Group on hereditary colorectal cancer funded by the German Cancer Aid (Deutsche Krebshilfe)]. Pathologe 2004 May;25 (3):178-92.

 

Schiemann U, Gunther S, Gross M, Henke G, Muller-Koch Y, Konig A, Muders M, Folwaczny C, Mussack T, Holinski-Feder E. Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer. Cancer Detect Prev 2005;29 (4):356-60.

Schiemann U, Muller-Koch Y, Gross M, Daum J, Lohse P, Baretton G, Muders M, Mussack T, Kopp R, Holinski-Feder E. Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation with clinical features. Digestion 2004;69 (3):166-76.

 

Schiemann U, Muller-Koch Y, Gross M, Glas J, Baretton G, Muders M, Mussack T and Holinski-Feder E. Detection of occult high graded microsatellite instabilities in MMR gene mutation negative HNPCC tumors by addition of complementary marker analysis. Eur J Med Res 2005b;10(1): 23-8.

 

Schulmann K, Brasch FE, Kunstmann E, Engel C, Pagenstecher C, Vogelsang H, Kruger S, Vogel T, Knaebel HP, Ruschoff J, Hahn SA, Knebel-Doeberitz MV, Moeslein G, Meltzer SJ, Schackert HK, Tympner C, Mangold E, Schmiegel W. HNPCC-associated small bowel cancer: clinical and molecular characteristics. Gastroenterology 2005 Mar;128 (3):590-9.

 

Schulmann K, Hollerbach S, Kraus K, Willert J, Vogel T, Moslein G, Pox C, Reiser M, Reinacher-Schick A, Schmiegel W. Feasibility and diagnostic utility of video capsule endoscopy for the detection of small bowel polyps in patients with hereditary polyposis syndromes. Am J Gastroenterol 2005 Jan;100 (1):27-37.

 

Schulmann K, Mangold E, Schmiegel W, Propping P. Wirksamkeit der Krebsfrüherkennung beim hereditären kolorektalen Karzinom ohne Polyposis (HNPCC). Deutsches Ärtzeblatt 2004; 101:A506-A512

 

Schulmann K, Schmiegel W. Capsule endoscopy for small bowel surveillance in hereditary intestinal polyposis and non-polyposis syndromes. Gastrointest Endosc Clin N Am 2004 Jan;14 (1):149-58.

 

Schumacher V, Vogel T, Leube B, Driemel C, Goecke T, Moslein G, Royer-Pokora B. STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. J Med Genet 2005 May;42 (5):428-35.

 

Schwitalle Y, Linnebacher M, Ripberger E, Gebert J, von Knebel Doeberitz M. Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells. Cancer Immun 2004 Nov 25;4:14.

 

Singer G, Kallinowski T, Hartmann A, Dietmaier W, Wild PJ, Schraml P, Sauter G, Mihatsch MJ, Moch H. Different types of microsatellite instability in ovarian carcinoma. Int J Cancer. 2004 Nov 20;112(4):643-6.

 

Sutter C, Dallenbach-Hellweg G, Schmidt D, Baehring J, Bielau S, von Knebel Doeberitz M, Gebert J. Molecular analysis of endometrial hyperplasia in HNPCC-suspicious patients may predict progression to endometrial carcinoma. Int J Gynecol Pathol 2004 Jan;23 (1):18-25.

 

Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004 Feb 18;96 (4):261-8.

 

Volmer MW, Radacz Y, Hahn SA, Klein-Scory S, Stuhler K, Zapatka M, Schmiegel W, Meyer HE, Schwarte-Waldhoff I. Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis. Proteomics 2004 May;4 (5):1324-34.

 

Wehner M, Mangold E, Sengteller M, Friedrichs N, Aretz S, Friedl W, Propping P, Pagenstecher C. Hereditary nonpolyposis colorectal cancer: pitfalls in deletion screening in MSH2 and MLH1 genes. Eur J Hum Genet 2005 Aug;13 (8):983-6.

 

Wild PJ, Reichle A, Andreesen R, Rockelein G, Dietmaier W, Ruschoff J, Blaszyk H, Hofstadter F, Hartmann A. Microsatellite instability predicts poor short-term survival in patients with advanced breast cancer after high-dose chemotherapy and autologous stem-cell transplantation. Clin Cancer Res 2004 Jan 15;10 (2):556-64.

 

Wild PJ, Stoehr R, Knuechel R, Hartmann A, Dietmaier W. Laser microdissection for microsatellite analysis in colon and breast cancer. Methods Mol Biol 2005;293:93-101.

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